WADA S2
This substance falls under WADA S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics). If you are subject to anti-doping rules, this category of substances is prohibited at all times.
Sequence Ambiguity
Significant sequence ambiguity exists for this product in the market. Vendors must specify exact peptide sequence, and products should not be assumed interchangeable with related full-length peptides or fragments.
Evidence visual
TB-500 evidence and risk matrix
intermediate researcher fit
Evidence
Tier C
Risk
med high
Regulatory
not approved
WADA
S2
FDA
unknown
Route
subcutaneous
Mixed evidence profile. Useful for comparison, not a standalone protocol decision.
Overview
TB-500 is often marketed as a thymosin beta-4-derived fragment, specifically the LKKTETQ actin-binding motif (residues 17-23). Clinical evidence for TB-500 per se is limited compared to full-length thymosin beta-4. Sequence ambiguity between TB-500 and full Tβ4 is a material concern — vendors must specify exact sequence. WADA classifies thymosin-β4 derivatives under growth factor modulators.
Decision path
Where TB-500 fits in the research path.
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Peptide research path
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Use the quiz before choosing a compound, vendor, or PDF. It routes by goal, experience, budget, safety flags, and monitoring comfort.
Research Details
Actin-binding domain effects (cell migration and angiogenesis signatures) proposed; clinical evidence limited.
subcutaneous
Human evidence for TB-500 specifically is limited; thymosin beta-4 clinical work is more substantial.
Soft-tissue repair and recovery signals in preclinical models.
Preclinical: varies by injury model. Consumer timelines are speculative.
No established contraindications (insufficient data).
Limited safety data; sequence ambiguity adds quality risk.
Unknown/insufficient. Caution when combining with full-length thymosin beta-4 due to sequence overlap.
Cost at a glance
Typical cycle cost
$287.97
Estimated monthly
$143.98
Protocol style
6-10 week phase
Phase-based
Estimate confidence
High confidence
Assumes roughly 16 mg–32 mg per cycle, using 2 tracked affiliated listings.
Modeled as a multi-week recovery block with possible taper or maintenance later.
Age, sex, and monitoring
Life-stage fit
Usually framed as a recovery compound for active adults rather than a later-life maintenance tool.
Best fit age ranges: 25-34, 35-44, 45-54
65+
Experimental status and limited human evidence make this a poor fit for older adults.
Known Interactions
TB-500 is often described as a thymosin beta-4 fragment/region; must confirm exact sequence and avoid mixing fragment vs full-length assumptions.
Commonly marketed as a stack/blend in consumer market; clinical interaction evidence limited; treat as uncertain.
Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.
Sources and review notes
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks - U.S. Food and Drug Administration - accessed 2026-05-15
Used for FDA compounding-risk context and peptide safety flags.
- The Prohibited List - World Anti-Doping Agency - accessed 2026-05-15
Used for athlete-facing WADA risk and peptide-class restrictions.
- Peptide therapeutics: current status and future directions - PubMed / Nature Reviews Drug Discovery - accessed 2026-05-15
Used for broad peptide-therapeutics background and evidence framing.
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