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BPC-157

Also known as Body Protection Compound 157 · PL 14736 · stable gastric pentadecapeptide

Preclinical cytoprotective peptide studied for tissue repair and GI protection in animal models.

Tier Cmed–high riskintermediateWADA S0FDA Flagged
Tier C
Evidence
4-6 week burst
Protocol
med–high
Risk
subcut.
Route

FDA Safety Flag

The FDA has identified this substance as one that may present significant safety risks when used in compounding, including concerns about immunogenicity, impurity characterization, and/or insufficient safety information.

WADA S0

This substance is explicitly listed under WADA S0 (Non-Approved Substances). If you are subject to anti-doping rules, use of this substance is prohibited at all times.

Not Approved

This substance is not approved by any major regulatory body for human therapeutic use. All information is derived from preclinical research, limited clinical studies, or off-label contexts.

Evidence visual

BPC-157 evidence and risk matrix

intermediate researcher fit

Evidence

Tier C

Risk

med high

Regulatory

not approved

WADA

S0

FDA

flagged

Route

subcutaneous

Mixed evidence profile. Useful for comparison, not a standalone protocol decision.

Overview

BPC-157 is a 15-amino-acid peptide derived from a protein found in human gastric juice. Preclinical literature describes cytoprotective, angiogenic, and NO-system modulation signals, but the mechanism is not settled and is largely inferred from animal models. FDA has warned that compounded drugs containing BPC-157 may pose risks including immunogenicity concerns and insufficient safety information for proposed routes. WADA explicitly lists BPC-157 under S0 non-approved substances.

Decision path

Where BPC-157 fits in the research path.

Use the evidence and risk profile first, then compare vendors and run the quiz before turning this compound into a protocol decision.

1 related goal
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    Read evidence

  2. 02

    Check risk

  3. 03

    Compare options

  4. 04

    Build plan

Peptide research path

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Use the quiz before choosing a compound, vendor, or PDF. It routes by goal, experience, budget, safety flags, and monitoring comfort.

Research Details

Mechanism of Action

Preclinical cytoprotective and angiogenic signaling via NO-system modulation; mechanism not settled, largely inferred from animal models.

Administration Routes

subcutaneous, oral

Study Dose Range

Rodent: ~10 µg/kg systemic; oral exposure at µg/kg levels. No established human dosing.

Expected Effects

Preclinical: angiogenesis markers, tissue repair signals, GI mucosal protection in rodent models.

Dosing Timeline

Animal models: endpoints assessed over days to weeks (2-4 weeks in injury models).

Contraindications

No established human contraindications (insufficient data).

Adverse Effects

Insufficient human data; immunogenicity risk flagged by FDA; impurity characterization concerns.

Interaction Notes

No robust human interaction map; avoid confident stacking claims.

Cost at a glance

Typical cycle cost

$118.99

Estimated monthly

$79.32

Protocol style

4-6 week burst

Short burst

Estimate confidence

High confidence

Assumes roughly 8 mg14 mg per cycle, using 2 tracked affiliated listings.

Modeled as a short repair-focused run rather than an indefinite therapy.

Age, sex, and monitoring

Life-stage fit

Commonly researched by active adults for recovery, but still lacks validated human age-specific evidence.

25-3435-4445-5455-64

Best fit age ranges: 25-34, 35-44, 45-54

65+

Very limited human evidence makes this a weak fit for older-adult decision-making.

Known Interactions

Caution

TB-500

Commonly marketed as a stack/blend in consumer market; clinical interaction evidence limited; treat as uncertain.

Caution

Thymosin Beta-4

Commonly co-marketed; limited interaction evidence; treat as uncertain.

Frequently Compared

Compare top

Thymosin Beta-4

Tier B-C

TB-500

Tier C

MGF E-domain

Tier C

GHK-Cu

Tier B-C

Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.

Sources and review notes

  1. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks - U.S. Food and Drug Administration - accessed 2026-05-15

    Used for FDA compounding-risk context and peptide safety flags.

  2. The Prohibited List - World Anti-Doping Agency - accessed 2026-05-15

    Used for athlete-facing WADA risk and peptide-class restrictions.

  3. Peptide therapeutics: current status and future directions - PubMed / Nature Reviews Drug Discovery - accessed 2026-05-15

    Used for broad peptide-therapeutics background and evidence framing.

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