Humanin
Also known as HN · HNG · Humanin analogue
Mitochondrial-derived micropeptide with preclinical cytoprotective and neuroprotective research.
Not Approved
This substance is not approved by any major regulatory body for human therapeutic use. All information is derived from preclinical research, limited clinical studies, or off-label contexts.
No Human Data
No human exposure data has been identified for this substance. All available evidence comes from animal models or in vitro studies. Safety in humans is completely unknown.
Evidence visual
Humanin evidence and risk matrix
advanced researcher fit
Evidence
Tier C
Risk
med high
Regulatory
not approved
WADA
none
FDA
unknown
Route
subcutaneous
Mixed evidence profile. Useful for comparison, not a standalone protocol decision.
Overview
Humanin (and its potent analogue HNG) is a mitochondrial-derived micropeptide. Cytoprotective and neuroprotective actions are described in reviews with proposed roles in mitochondrial stress and metabolic regulation. Stroke/neuroprotection models exist preclinically. Unknown safety in humans.
Decision path
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Research Details
Cytoprotective and neuroprotective actions; proposed roles in mitochondrial stress and metabolic regulation.
subcutaneous
Preclinical and limited translational; stroke/neuroprotection models.
Preclinical: cytoprotection, neuroprotection. No proven human benefit.
Model-dependent in preclinical studies.
No data.
Unknown in humans.
Unknown.
Cost at a glance
No reliable cycle cost estimate yet. We need cleaner listing price and pack-size data before showing a trustworthy number.
Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.
Sources and review notes
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks - U.S. Food and Drug Administration - accessed 2026-05-15
Used for FDA compounding-risk context and peptide safety flags.
- The Prohibited List - World Anti-Doping Agency - accessed 2026-05-15
Used for athlete-facing WADA risk and peptide-class restrictions.
- Peptide therapeutics: current status and future directions - PubMed / Nature Reviews Drug Discovery - accessed 2026-05-15
Used for broad peptide-therapeutics background and evidence framing.
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