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AOD-9604

Also known as hGH fragment 176-191 · GH hexadecapeptide

GH fragment studied in human obesity trials for lipolytic effects via β-adrenergic pathways.

Tier Bmed–high riskintermediateWADA S2
Tier B
Evidence
12-24 week phase
Protocol
med–high
Risk
oral
Route

WADA S2

This substance falls under WADA S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics). If you are subject to anti-doping rules, this category of substances is prohibited at all times.

Evidence visual

AOD-9604 evidence and risk matrix

intermediate researcher fit

Evidence

Tier B

Risk

med high

Regulatory

not approved

WADA

S2

FDA

unknown

Route

oral

Higher-confidence evidence profile, but regulatory and sourcing checks still matter.

Overview

AOD-9604 is proposed to capture the lipolytic signaling of GH without full GH receptor effects. Mouse studies describe interaction with β-adrenergic pathways (β3-AR) and increased lipolytic sensitivity. Human obesity trials include daily oral dosing across 1-30 mg/day ranges in 12-week designs. Weight loss signals were modest. WADA lists AOD-9604 and hGH fragments as GH fragments under S2.

Decision path

Where AOD-9604 fits in the research path.

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Research Details

Mechanism of Action

Proposed lipolytic signaling of GH without full GH receptor effects; β3-AR pathway interaction described in mice.

Administration Routes

oral, subcutaneous

Study Dose Range

Human obesity trials: oral 1-30 mg/day for 12 weeks.

Expected Effects

Modest lipolytic/fat loss signals in trials. Not equivalent to GLP-1 class.

Dosing Timeline

Clinical trials measured outcomes over ~12 weeks; weight loss signals modest.

Contraindications

No formal label.

Adverse Effects

Overall tolerability similar to placebo in safety reports; some serious AEs in dose groups (judged unrelated by investigators).

Interaction Notes

Minimal established interactions.

Cost at a glance

Typical cycle cost

€963.31

Estimated monthly

€321.10

Protocol style

12-24 week phase

Phase-based

Estimate confidence

High confidence

Assumes roughly 84 mg168 mg per cycle, using 1 tracked affiliated listing.

Reflects fat-loss style use over a longer multi-month block rather than a single month.

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Information provided for educational and research reference only. Not medical advice. Not for diagnosing, treating, curing, or preventing disease. Products referenced are labeled Research Use Only (RUO) by vendors; not for human or veterinary use.

Sources and review notes

  1. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks - U.S. Food and Drug Administration - accessed 2026-05-15

    Used for FDA compounding-risk context and peptide safety flags.

  2. The Prohibited List - World Anti-Doping Agency - accessed 2026-05-15

    Used for athlete-facing WADA risk and peptide-class restrictions.

  3. Peptide therapeutics: current status and future directions - PubMed / Nature Reviews Drug Discovery - accessed 2026-05-15

    Used for broad peptide-therapeutics background and evidence framing.

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