Compare · Head-to-head
CJC-1295 vs MGF E-domain.
Evidence, risk, regulatory flags, cost, and vendor coverage compared side by side. We don’t sell peptides — we help you choose between them.
Which should you research first?
Start with CJC-1295, then use the table to confirm fit.
CJC-1295 is the cleaner first read based on the current evidence, risk, and regulatory data stored for this pair. The right answer can still change if your goal, sport testing status, vendor constraints, or monitoring tolerance makes the other option a better fit.
Comparison next step
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Take the quiz before converting a comparison into a compound, vendor, or protocol decision.
01 · At a glance
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Primary fit | muscle growth & strength and fat loss & metabolism comparisons | muscle growth & strength and tissue repair & recovery comparisons |
| Evidence | Tier B | Tier C |
| Risk | high | extreme |
| Experience level | intermediate | advanced |
| Budget tier | mid | mid |
| Administration route | subcutaneous | subcutaneous |
02 · Use case & timing
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Goal fit | Muscle Growth & Strength, Fat Loss & Metabolism, GH Axis Optimization | Muscle Growth & Strength, Tissue Repair & Recovery |
| What users compare it for | Sustained GH and IGF-1 elevation; body composition modulation (long-horizon, not well-established for consumer outcomes). | Muscle repair signaling in preclinical models. |
| Onset timeline | Biomarker effects persist multiple days; IGF-1 elevations up to ~2 weeks after single dose. | Preclinical outcomes vary by model. |
| Main tradeoff | Evidence is stronger than most compounds in this category, but route, side effects, and vendor fit still matter. | Potential upside comes with much more safety and screening caution than lower-risk alternatives. |
03 · Safety & restrictions
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Adverse effects | Injection-site reactions, headache, diarrhea, flushing, transient hypotension at higher doses. | Limited data; growth-factor class concerns apply. |
| Contraindications | GH-axis stimulation risks: glucose intolerance, theoretical neoplasia concerns with elevated IGF-1. | No human data. |
| Interaction notes | Monitor insulin/glucose sensitivity, thyroid axis, and cortisol/prolactin. Trials report no significant cortisol/prolactin/TSH/LH increases at 60 µg/kg single dose. | Unknown. |
| Regulatory status | Not approved | Not approved |
| FDA flag | FDA compounding caution | FDA status unclear |
| WADA status | WADA S2 | WADA S2 |
04 · Age & monitoring
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Supported age ranges | 25-34, 35-44, 45-54 | No age guidance yet |
| Life-stage note | Midlife is where GH-restoration framing is most often used, but evidence and long-term safety remain limited. | Not yet documented |
| Monitoring burden | high | Not specified |
| Follow-up cadence | Reassess at startup and then roughly every few months if continuing. | Not yet documented |
05 · Cost & sourcing
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Typical cycle cost | $143.98 | No reliable estimate yet |
| Estimated monthly cost | $47.99 | No reliable estimate yet |
| Cost confidence | High confidence | No estimate |
06 · Before you buy
| Decision factor | CJC-1295 | MGF E-domain |
|---|---|---|
| Tracked vendor listings | 3 listings | 0 listings |
| Sourcing note | At least one listing is a blend rather than a clean standalone product, so review the product page carefully. | No tracked product page yet, so sourcing takes more manual review. |
| Stack-friendly? | Usually stack-friendly | Usually stack-friendly |
Sources and review notes
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks - U.S. Food and Drug Administration - accessed 2026-05-15
Used for FDA compounding-risk context and peptide safety flags.
- The Prohibited List - World Anti-Doping Agency - accessed 2026-05-15
Used for athlete-facing WADA risk and peptide-class restrictions.
- Peptide therapeutics: current status and future directions - PubMed / Nature Reviews Drug Discovery - accessed 2026-05-15
Used for broad peptide-therapeutics background and evidence framing.
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